Good listening is an essential element in the provision of quality healthcare (Attree 2001). Good listening also supports accurate diagnosis, patient adherence to medical recommendations, and stron...

Large-scale sequencing tests, including whole-exome and whole-genome sequencing, are rapidly moving into clinical use. Sequencing is already being used clinically to identify therapeutic opportunities for cancer patients who have run out of conventional treatment options, to help diagnose children with puzzling neurodevelopmental conditions, and to clarify appropriate drug choices and dosing in individuals. To evaluate and support clinical applications of these technologies, the National Human Genome Research Institute and National Cancer Institute have funded studies on clinical and research sequencing under (...) the Clinical Sequencing Exploratory Research program as well as studies on return of results. Most of these studies use sequencing in real-world clinical settings and collect data on both the application of sequencing and the impact of receiving genomic findings on study participants. They are occurring in the context of controversy over how to obtain consent for exome and genome sequencing. (shrink)

Chefs have been recognized as potentially important partners in efforts to promote local food systems. Drawing on the diffusion of innovation framework we (a) examine the characteristics of chefs and restaurants that have adopted local foods; (b) identified local food attributes valued by restaurants; (c) examine how restaurants function as opinion leaders promoting local foods; (d) explored network linkages between culinary and production organizations; and (e) finally, we consider some of the barriers to more widespread adoption of local foods in (...) the culinary community. Analyzing quantitative and qualitative data collected from interviews with individuals from 71 restaurants, we compare and contrast restaurants that utilize relatively large amounts of locally-produced ingredients with restaurants using few, if any, local products. Results reveal that chefs are most interested in intrinsic food qualities, such as taste and freshness, and less interested in production standards. As opinion leaders, chefs utilize signage, wait staff, and cooking classes to promote local foods; however, the diffusion process across restaurants, and between restaurants and producers, is limited by network associations. Structural barriers such as distribution problems and lack of convenience were identified as limiting more widespread use of locally-grown foods. We offer several implications of this research for further work that seeks to engage chefs as opinion leaders who are important to building greater support for local food systems. (shrink)

A book which might well become a classic on Heidegger. Richardson discusses most of Heidegger's works in chronological order, offering a close analysis of each. Most chapters include a general exposition of the argument of the work discussed, a detailed analysis of the problems of Thought, Being and Dasein in the work, and a résumé. While maintaining very high standards of scholarly precision in the rendering of Heidegger's ideas and terminology, Richardson yet succeeds in making his book very readable and (...) lucid. Without "supplementing" Heidegger in any way, refraining from explanatory speculations and staying always very close to the text, he manages to clarify some of the most difficult passages of Heidegger's works. His frequent cross-references make the commentary of genuine value to the advanced student as well as to the novice. Heidegger, in his own preface to the book, criticizes Richardson for the sharp distinction between Heidegger I and Heidegger II, but gives a most important substantiation to two of the author's main theories, viz., the difference between Heidegger's Seinsdenken and Husserl's phenomenology, and the central status of the concept of Ereignis in Heidegger's philosophy. Richardson regrettably does not pursue the Heidegger III suggested by Vycinas, the Heidegger of the Geviert, the question of the nature of Being as such. In some chapters at least this omission makes the interpretation seem partial and sometimes inexact. One hopes for a sequel as good and illuminating.—E. M. Z. (shrink)

This volume ranges in time over a very long period and covers the Greeks' most original contributions to intellectual history. It begins and ends with philosophy, but it also includes major sections on historiography and oratory. Although each of these areas had functions which in the modern world would not be considered 'Literary', the ancients made a less sharp distinction between intellectual and artistic production, and the authors included in this volume are some of Europe's most powerful stylists: Plato, Herodotus, (...) Thucydides and Demosthenes. (shrink)

The issues between naturalism and subjectivism are brought into sharp focus, mainly through a critical examination of Husserl's phenomenology, with the author defending not only naturalism, but the view that only by a pluralism of methods can an adequate philosophy of experience be attained. Farber criticizes Husserl for failing to recognize that his method, rather than experience itself, generates some of the problems he attempted to solve. The movement from subjectivism to "irrationalism,", is briefly accounted for by considering Heidegger, Jaspers, (...) Marcel and Sartre. An important book, occasionally sardonic and humorous.--J. E. M. (shrink)

Carol Gilligan has identified two orientations to moral understanding; the dominant justice orientation and the under-valued care orientation. Based on her discernment of a voice of care, Gilligan challenges the adequacy of a deontological liberal framework for moral development and moral theory. This paper examines how the orientations of justice and care are played out in medical ethical theory. Specifically, I question whether the medical moral domain is adequately described by the norms of impartiality, universality, and equality that characterize the (...) liberal ideal. My analysis of justice -oriented medical ethics, focuses on the libertarian theory of H.T. Engelhardt and the contractarian theory of R.M. Veatch. I suggest that in the work of E.D. Pellegrino and D.C. Thomasma we find not only a more authentic representation of medical morality but also a project that is compatible with the care orientation's emphasis on human need and responsiveness to particular others. (shrink)

We present a method for assessing the sensitivity of the true causal effect to unmeasured confounding. The method requires the analyst to set two intuitive parameters. Otherwise, the method is assumption free. The method returns an interval that contains the true causal effect and whose bounds are arbitrarily sharp, i.e., practically attainable. We show experimentally that our bounds can be tighter than those obtained by the method of Ding and VanderWeele, which, moreover, requires to set one more parameter than our (...) method. Finally, we extend our method to bound the natural direct and indirect effects when there are measured mediators and unmeasured exposure–outcome confounding. (shrink)

Before dealing directly with the content of Urban's thought, there remains to be singled out one of its general traits, a grasp of which is absolutely necessary for any understanding of his thought. From the beginning, Urban's philosophy has exhibited a refusal to accept any ultimate impasse in thought. His is the understanding or irenic type of view over against the one-sided or polemic type. For him, reason is always comprehensive enough to sustain differences of opinion, and it is able, (...) if one goes deeply enough, to show the relativity of all exclusive oppositions in philosophical thought. There is an almost Hegelian passion for synthesis in his dogged attempts to get beyond certain disagreements between philosophical positions. It was his wont to regard impasses in thought as futile in the precise sense that neither side is able to refute the other simply because there is a sense in which both are right and both are wrong. Many illustrations from the writings of what might be called this "transcending" approach can be given: in History he seeks to show the two-fold nature of sufficient reason as both logical and ontological and approves of Kant's attempt to establish a mediating position beyond both; in Valuation the attempt is made to get "beyond the dichotomy of 'appreciation' and 'description' "; in Intelligible the view is taken that logical values are neither "existent" nor "subsistent" but "simply valid" which view is said to be beyond special ontological prejudices; in Humanity Urban is concerned to show that the religious tradition of the West has been beyond the ultimate antithesis of pure deity or mere humanity and that an indissoluble relation between the two has always been acknowledged and accepted; the attempt to get "beyond" occupies, of course, the whole of Beyond, and need not be singled out for special attention at this juncture. These illustrations are only a few of many; in calling attention to this general trait, however, it must not be thought that anything more is intended than the emphasizing of a singularly important feature of Urban's thought. Such a trait, howsoever clearly understood, would still leave us far from an adequate comprehension of his idealism; but without taking it into account his views will often appear to lack sharpness and conviction. All that can be said is that these are some of the disadvantages of a harmonizing or transcending position. (shrink)

Many real-world agents recognise that they impose harms by choosing to emit carbon, e.g., by flying. Yet many do so anyway, and then attempt to make things right by offsetting those harms. Such offsetters typically believe that, by offsetting, they change the deontic status of their behaviour, making an otherwise impermissible action permissible. Do they succeed in practice? Some philosophers have argued that they do, since their offsets appear to reverse the adverse effects of their emissions. But we show that (...) they do not. In practice, standard carbon offsetting does not reverse the harms of the original action, nor does it even benefit the same group as was harmed. Standard moral theories hence deny that such offsetting succeeds. Indeed, we show that any moral theory that allows offsetting in this setting faces a dilemma between allowing any wrong to be offset, no matter how grievous, and recognising an implausibly sharp discontinuity between offsettable actions and non-offsettable actions. The most plausible response is to accept that carbon offsetting fails to right our climate wrongs. (shrink)

Cappelen and Hawthorne’s Relativism and Monadic Truth (2009) offers an extended defense of a thesis they call simplicity, which, in brief, holds that propositions are true or false simpliciter. Propositions are cast in their traditional roles as the contents of assertions, and as the semantic values of declarative sentences in contexts. Simplicity stands in sharp contrast to forms of relativism including, for instance, a form that hold that our claims are true or false only relative to a judge. This applies (...) especially to claims of taste, which come out true or false only relative to the judge who finds things tasty (e.g. Glanzberg 2007, Lasersohn 2005). But simplicity also rejects the more widespread temporalist view that propositions are true or false only relative to a time, and it rejects the even more widely held view that propositions are true or false only relative to a world. One reason that has been advanced for temporalism, e.g. by Kaplan (1989), is that our languages seem to contain non-trivial temporal operators. Hence, the argument goes, the semantic values of sentences need to be temporally neutral, i.e. vary for truth or falsehood with time. The same goes for possible worlds and modal operators. Hence, Kaplan and many others think of the semantic values of sentences as sets of world-time pairs. It has been tempting to apply this sort of argument much more widely, to see the semantic values of sentences as varying not just with world and time, but perhaps with location and other parameters as well. Kaplan.. (shrink)

In this paper we discuss the epistemological positions of evolution theories. A sharp distinction is made between the theory that species evolved from common ancestors along specified lines of descent (here called the theory of common descent), and the theories intended as causal explanations of evolution (e.g. Lamarck's and Darwin's theory). The theory of common descent permits a large number of predictions of new results that would be improbable without evolution. For instance, (a) phylogenetic trees have been validated now; (b) (...) the observed order in fossils of new species discovered since Darwin's time could be predicted from the theory of common descent; (c) owing to the theory of common descent, the degrees of similarity and difference in newly discovered properties of more or less related species could be predicted. Such observations can be regarded as attempts to falsify the theory of common descent. We conclude that the theory of common descent is an easily-falsifiable & often-tested & still-not-falsified theory, which is the strongest predicate a theory in an empirical science can obtain. Theories intended as causal explanations of evolution can be falsified essentially, and Lamarck's theory has been falsified actually. Several elements of Darwin's theory have been modified or falsified: new versions of a theory of evolution by natural selection are now the leading scientific theories on evolution. We have argued that the theory of common descent and Darwinism are ordinary, falsifiable scientific theories. (shrink)

The title refers to Anselm's insight into the modal uniqueness of the divine existence and the proof based upon it in Proslogium III. Hartshorne continues his vigorous defense of "the Proof," his polemic against its critics, most of whom confuse it with the weaker one in Proslogium II, and his attempt to show that Anselm's discovery is ultimately viable only in the context of neo-classical theism. In the second half of the book a variety of responses to the proof, from (...) Gaunilo to several contemporaries, are examined and criticized. While this does not add substantially to the presentation and defense of the argument given in the first half, it does provide ample evidence of the way in which a host of philosophical questions are brought into sharp focus by reflecting on Anselm. Some of these, e.g., the theory of modalities, receive important attention which was lacking in The Logic of Perfection. The author's own position has not changed, though he now seems more impressed than previously by Barth's treatment of Anselm.—M. W. (shrink)

In this interview, Jean-Luc Marion recalls the intellectual world of Paris in 1970s, reflecting on how his engagement with the ubiquitous “death of God” question led to the sketches of God without Being first presented at this 1979 Colloquium, and discusses the criticism it provoked not only from Heideggerians but also from Thomists. He discusses the reception history of phenomenology in France the reasons for the particular power it gained among thinkers of his generation. Finally, he recounts how his work (...) has led from the 1979 Colloquium through the “Theological Turn” and up to his forthcoming D’ ailleurs, la révélation, which he briefly previews here. Marion closes with words on originality, criticism, and the particular challenges of the contemporary world that await philosophical thinking today. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:276 THE WILL AS IMPRESSION Hume writes, in the Treatise: Let no one, therefore, put an invidious construction on my words, by saying simply, that I assert the necessity of human actions, and place them on the same footing with the operations of senseless matter. I do not ascribe to the will that unintelligible necessity, which is suppos'd to lie in matter. But I ascribe to matter, that intelligible (...) quality, call it necessity or not, which the most rigorous orthodoxy does or must allow to belong to the will. I^ change, therefore, nothing in the receiv'd systems, with regard to the will, but only with regard to material objects. It is surely false that Hume changed "nothing in the receiv'd systems, with regard to the will." In one such "receiv'd system," that of Thomas Aquinas, the concept of will or volition is presented as internally related to two further concepts: that of the "final cause" or goal of the action, and that of "practical intellect," a form of cognition which is productive of its object. Will is always the will to something, a goal to be reached or a product to be produced. Thus will and final cause are concepts which presuppose one another. The mark, however, of the fact that someone wills to do something, i.e., that s/he in fact has some goal, is precisely that that agent knows, non-inductively and without observation, what s/he is doing or will do. The basis of this knowledge is neither evidence nor proof, but rather what Aristotle called "the practical syllogism." We will ask below what it means to describe the relationships among will, final cause, and practical knowledge as 'internal.' 277 The question to be explored here is this: what in fact becomes of the 'receiv'd concept of will' when one contends, in the empiricist spirit common to both Locke and Hume, that all of our knowledge about matters of fact is based on observation and induction? The answer to this question will turn out to be that, in the absence of a notion of "practical knowledge," the concept of final cause becomes unintelligible (since the final cause is precisely the object of practical knowledge); and thus the notion of will must be reconstrued, for Hume as an impression. As an impression it is a brute given, one that is furthermore mute (or lacking in propositional content). Hume views volition as an event, that object of inner experience which is the (Humean) cause of our voluntary actions. In what follows I shall first of all sketch Thomas Aquinas' view of the will (section I), following this with a discussion of the important hybrid view in Locke's Essay, where older notions of volition are presented within an incompatible epistemological framework. In section III we look at Hume's sharp response to Locke, and in section IV at his own doctrine of the will as impression. In the final section I attempt to distinguish two strands of causality in Hume's philosophy of human action, drawing at the same time a moral for the contemporary dispute about reasons and causes. One of the most fully developed of the "receiv'd systems with regard to the will" was that of St. Thomas Aquinas, who combined Neo-Platonist, Patristic, and Aristotelian sources into an 2 impressive and influential synthesis. Thomas' 278 doctrine on the will is guided by a Grand Analogy, one inspired by the Creation story in Genesis. He writes, at the beginning of the second main part of his Summa : Man is made to God's image, and since this implies... that he is intelligent and free to judge and master of himself, so then, now that we have agreed [in part one of the Summa] that God is the exemplar cause of things and that they issue from his power through his will, we go on to look at this image, that is to say, at man as the source of actions which are his own and fall under his responsibility and control. The analogy is this: God, the Divine Craf tsperson, is to the Creation as human agents are to their... (shrink)

The ancient Stoics notoriously argued, with thoroughness and force, that all ordinary “emotions” (passions, mental affections: in Greek, pãyh) are thoroughly bad states of mind, not to be indulged in by anyone, under any circumstances: anger, resentment, gloating; pity, sympathy, grief; delight, glee, pleasure; impassioned love (i.e. ¶rvw), agitated desires of any kind, fear; disappointment, regret, all sorts of sorrow; hatred, contempt, schadenfreude. Early on in the history of Stoicism, however, apparently in order to avoid the objection that human nature (...) itself demands and indeed justifies—under certain circumstances at any rate—emotional attachments to or aversions from, and reactions to, some persons, things, and happenings, they introduced a theory of what came to be called eÈpãyeiai, good and acceptable ways of feeling or being affected. For short I will render these in English by “good feelings.”1 They divided these into three generic kinds, which they dubbed “joy” (xarã), “wish” (boÊlhsiw) and “caution” (eÈlãbeia). They ranged these alongside, and set them in sharp contrast to, three of the four highest genera into which they divided the normal human emotions: “pleasure” (≤donÆ), i.e., being pleased about something,2 “appetitive desire” (§piyuµ€a), and “fear” (fÒbow), respectively. The Stoics maintained that, though ordinary, familiar human emotions such as these last-named ones were always bad, the three sorts of “good feeling,” and their more specific variations (since these three are only the basic genera into which lots of other good ways of feeling will fall), were not merely free from the grounds of criticism on which ordinary emotions were rejected, and so were perfectly acceptable. The fully perfected human being (the “wise person”) would indeed regularly be subject to them.3 Their theory of the perfect human life did not, then, they could claim, require any outrageously unnatural demand, presumably unrealizable in any case, for a life completely without all feelings of involvement in the sweep and flow of life.. (shrink)

Thomas Szasz's emphasis on goal-oriented behavior and moral responsibility has raised profound theoretical questions about an ancient and enduring problem in philosophy, the relationships amongfree will, determinism, and moral responsibility. Two early thinkers, Jonathan Edwards and Aristotle, have both contributed to an understanding of this dilemma. Edwards (1754) demonstrated that the concept of man as a moral agent and the doctrine of philosophical necessity are inextricably intertwined, in opposition to the tenets of contingency, moral indifference, and self-determining volition. However, his (...) argument rested on efficient causationalone. For further light on the problem we can turn to Aristotle's writings, notably the distinguishing criteria of the ‘practical’ sciences (including psychology) as opposed to the theoretical and the productive sciences; and multiple causation, one of the most powerful tools for intellectual analysis ever invented, which includes material, formal, and final causes as well as the efficient cause. The implications of Szasz's work force a re-examination of the contributions of both Edwards and Aristotle and make them relevant to contemporary psychiatry. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Critical Essays on Samuel Taylor ColeridgeWilliam E. CainCritical Essays on Samuel Taylor Coleridge, edited by Leonard Orr; vi & 194 pp. New York: Twayne, 1994, $42.00.“Coleridge, as you doubtless hear, is gone,” wrote Thomas Carlyle, August 12, 1834, to Ralph Waldo Emerson: “How great a Possibility, how small a realized Result.” There is now a huge Coleridge industry in the academy, engaged in producing editions of his writings (...) and examinations of his literary career. Yet Carlyle’s judgment continues to carry weight with many nonspecialist readers, who know Coleridge only as Wordsworth’s estimable friend and as the author of a handful of superb lyrics and radiant critical speculations in the Biographia Literaria (1817). These texts are indeed rich and suggestive: readers wish that there were more like them and that Coleridge’s achievement had somehow been greater, more monumental, like Wordsworth’s. Coleridge’s “misfortune,” concluded Carlyle’s friend, John Sterling, in January 1842, “was to appear at a time when there was a man’s work to do—and he did it not.”But the wish that Coleridge had been more than he was is misplaced, in large measure for the reason that it neglects the vast amount of significant work that he did accomplish—not only in poetry and criticism, but in philosophy, political journalism, social theory, and other disciplines and areas of thought. Experts in Romanticism know this work (or, at least, know of it), yet it has not [End Page 151] been excerpted in anthologies, contextualized and explained for students, or brought forward for analysis, beyond the circle of avid Coleridgeans, to extend and complicate the commonplaces about this writer that still enjoy wide circulation.In this respect, Leonard Orr, editor of Critical Essays on Samuel Taylor Coleridge, perhaps has missed an opportunity. His collection is valuable as far as it goes; it reprints eight excellent essays along with two new ones, and Orr’s own concise, informed Introduction, with footnotes packed with bibliography, provides a lucid overview of Coleridge studies. But the focus is strangely limited, the conception of the writer’s career is dated and conventional, and the selection of essays is too restricted.One is grateful for this collection’s strengths even as one regrets its gaps and omissions. John Beer gives a good account of the Coleridge/Wordsworth relationship; Stuart Peterfreund nicely shows how “Coleridge’s failed political vision of European history” is redeemed “as part of his critical vision of the imagination”; James C. McKusick, Paul Magnuson, Andrew M. Cooper, James Engell, and Anne K. Mellor explore Coleridge’s poetry—though oddly there is no essay devoted primarily to “The Rime of the Ancient Mariner”; and Kathleen M. Wheeler, Lawrence Buell, and Jerome Christensen form a helpful unit of pieces on the Biographia Literaria. But readers will not find here anything more than brief mentions of, for example, Coleridge’s writings for The Watchman and The Friend, his striking interpretations of Shakespeare, Aids to Reflection, letters, notebooks, two Lay Sermons, and On the Constitution of the Church and State.This failure to supply broader, more innovative coverage is puzzling, given that the general aim of the series in which Orr’s book appears (Critical Essays on British Literature, gen. ed. Zack Bowen) is “to develop a new overall perspective on its particular subject.” Even more, Orr himself says in his Introduction that scholarship of the past two decades has prompted us to be “less likely to ignore the prose works beyond the Biographia” and has drawn attention to Coleridge’s marginalia and notebooks. Orr displays a sharp sense of the new Coleridge, yet has designed his book in a way that reflects the old one and that will tend for many readers simply to reinforce Carlyle’s adverse judgment.William E. CainWellesley CollegeCopyright © 1995 The Johns Hopkins University Press... (shrink)

Sterols and the reductant nicotinamide adenine dinucleotide phosphate (NADPH), essential for eukaryotic life, arose because of, and as an adaptation to, rising levels of molecular oxygen (O2). Hence, the NADPH and O2‐intensive process of sterol biosynthesis is inextricably linked to redox status. In mammals, cholesterol biosynthesis is exquisitely regulated post‐translationally by multiple E3 ubiquitin ligases, with membrane associated Really Interesting New Gene (RING) C3HC4 finger 6 (MARCHF6) degrading at least six enzymes in the pathway. Intriguingly, all these MARCHF6‐dependent enzymes require (...) NADPH. Moreover, MARCHF6 is activated by NADPH, although what this means for control of cholesterol synthesis is unclear. Indeed, this presents a paradox for how NADPH regulates this vital pathway, since NADPH is a cofactor in cholesterol biosynthesis and yet, low levels of NADPH should spare cholesterol biosynthesis enzymes targeted by MARCHF6 by reducing its activity. We speculate MARCHF6 helps mammalian cells adapt to oxidative stress (signified by low NADPH levels) by reducing degradation of cholesterogenic enzymes, thereby maintaining synthesis of protective cholesterol. (shrink)

We performed three experiments to investigate whether adjectives can modulate the sensorimotor activation elicited by nouns. In Experiment 1, nouns of graspable objects were used as stimuli. Participants had to decide if each noun referred to a natural or artifact, by performing either a precision or a power reach‐to‐grasp movement. Response grasp could be compatible or incompatible with the grasp typically used to manipulate the objects to which the nouns referred. The results revealed faster reaction times (RTs) in compatible than (...) in incompatible trials. In Experiment 2, the nouns were combined with adjectives expressing either disadvantageous information about object graspability (e.g., sharp) or information about object color (e.g., reddish). No difference in RTs between compatible and incompatible conditions was found when disadvantageous adjectives were used. Conversely, a compatibility effect occurred when color adjectives were combined with nouns referring to natural objects. Finally, in Experiment 3 the nouns were combined with adjectives expressing tactile or shape proprieties of the objects (e.g., long or smooth). Results revealed faster RTs in compatible than in incompatible condition for both noun categories. Taken together, our findings suggest that adjectives can shape the sensorimotor activation elicited by nouns of graspable objects, highlighting that language simulation goes beyond the single‐word level. (shrink)

The Birkhoff-Maltsev problem asks for a characterization of those lattices each of which is isomorphic to the lattice L(K) of all subquasivarieties for some quasivariety K of algebraic systems. The current status of this problem, which is still open, is discussed. Various unsolved questions that are related to the Birkhoff-Maltsev problem are also considered, including ones that stem from the theory of propositional logics.